WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Proteasome       ID:03050
C=44; O=5; E=0.13; R=38.59; rawP=2.03e-07; adjP=3.65e-06
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000087191 NA PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 5705 ENSG00000087191
2  ENSG00000159352 NA PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 5710 ENSG00000159352
3  ENSG00000100764 NA PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 5700 ENSG00000100764
4  ENSG00000125818 NA PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 9491 ENSG00000125818
5  ENSG00000165916 NA PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 5702 ENSG00000165916


Database:KEGG pathway       Name:RNA transport       ID:03013
C=151; O=6; E=0.44; R=13.49; rawP=6.08e-06; adjP=5.47e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000104408 NA EIF3E eukaryotic translation initiation factor 3, subunit E 3646 ENSG00000104408
2  ENSG00000150459 NA SAP18 Sin3A-associated protein, 18kDa 10284 ENSG00000150459
3  ENSG00000114784 NA EIF1B eukaryotic translation initiation factor 1B 10289 ENSG00000114784
4  ENSG00000130811 NA EIF3G eukaryotic translation initiation factor 3, subunit G 8666 ENSG00000130811
5  ENSG00000147677 NA EIF3H eukaryotic translation initiation factor 3, subunit H 8667 ENSG00000147677
6  ENSG00000101210 NA EEF1A2 eukaryotic translation elongation factor 1 alpha 2 1917 ENSG00000101210


Database:KEGG pathway       Name:Ubiquitin mediated proteolysis       ID:04120
C=135; O=4; E=0.40; R=10.06; rawP=0.0007; adjP=0.0042
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000119048 NA UBE2B ubiquitin-conjugating enzyme E2B 7320 ENSG00000119048
2  ENSG00000113558 NA SKP1 S-phase kinase-associated protein 1 6500 ENSG00000113558
3  ENSG00000103363 NA TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) 6923 ENSG00000103363
4  ENSG00000130725 NA UBE2M ubiquitin-conjugating enzyme E2M 9040 ENSG00000130725


Database:KEGG pathway       Name:Oocyte meiosis       ID:04114
C=112; O=3; E=0.33; R=9.10; rawP=0.0045; adjP=0.0203
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000113558 NA SKP1 S-phase kinase-associated protein 1 6500 ENSG00000113558
2  ENSG00000108953 NA YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 7531 ENSG00000108953
3  ENSG00000121281 NA ADCY7 adenylate cyclase 7 113 ENSG00000121281


Database:KEGG pathway       Name:Spliceosome       ID:03040
C=127; O=3; E=0.37; R=8.02; rawP=0.0064; adjP=0.0225
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000101161 NA PRPF6 PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) 24148 ENSG00000101161
2  ENSG00000132792 NA CTNNBL1 catenin, beta like 1 56259 ENSG00000132792
3  ENSG00000102103 NA PQBP1 polyglutamine binding protein 1 10084 ENSG00000102103


Database:KEGG pathway       Name:Vasopressin-regulated water reabsorption       ID:04962
C=44; O=2; E=0.13; R=15.44; rawP=0.0075; adjP=0.0225
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000185236 NA RAB11B RAB11B, member RAS oncogene family 9230 ENSG00000185236
2  ENSG00000144635 NA DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 51143 ENSG00000144635


Database:KEGG pathway       Name:Renal cell carcinoma       ID:05211
C=70; O=2; E=0.21; R=9.70; rawP=0.0182; adjP=0.0468
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000103363 NA TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) 6923 ENSG00000103363
2  ENSG00000134954 NA ETS1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 2113 ENSG00000134954


Database:KEGG pathway       Name:Glycerophospholipid metabolism       ID:00564
C=80; O=2; E=0.24; R=8.49; rawP=0.0234; adjP=0.0527
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000103502 NA CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 10423 ENSG00000103502
2  ENSG00000026652 NA AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) 56895 ENSG00000026652


Database:KEGG pathway       Name:Pyrimidine metabolism       ID:00240
C=99; O=2; E=0.29; R=6.86; rawP=0.0347; adjP=0.0694
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000102978 NA POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa 5432 ENSG00000102978
2  ENSG00000130717 NA UCK1 uridine-cytidine kinase 1 83549 ENSG00000130717


Database:KEGG pathway       Name:Cell cycle       ID:04110
C=124; O=2; E=0.37; R=5.48; rawP=0.0520; adjP=0.0936
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000113558 NA SKP1 S-phase kinase-associated protein 1 6500 ENSG00000113558
2  ENSG00000108953 NA YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 7531 ENSG00000108953




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).